Key result
Radiotherapy elevates BNP in left breast cancer, suggesting its potential as a cardiac damage biomarker.
Why the study?
To analyze whether BNP could serve as a biomarker for cardiac damage in breast cancer patients following radiotherapy.
Is BNP a potential biomarker for cardiac damage in breast cancer patients after radiotherapy?
Meta-Analysis (n=172)
Is BNP a potential biomarker for cardiac damage in breast cancer patients after radiotherapy?
BNP may serve as a biomarker for cardiac damage following radiotherapy in breast cancer patients, particularly those with left-sided breast cancer.
May support BNP monitoring to detect radiotherapy cardiotoxicity in left breast cancer; extends biomarker evidence but requires prospective validation.
BACKGROUND: To analyze whether BNP could be a potential biomarker for cardiac damage of breast cancer after radiotherapy. METHODS: PubMed, Web of Science, ProQuest and Medline were searched using the key words "breast cancer" ("breast tumor", "breast neoplasm", or "breast carcinoma"), "brain natriuretic peptide" (or BNP) and "radiotherapy" (or "radiation therapy"). Four articles were selected and analyzed using the STATA 12.0 software package. The standard mean difference (SMD) and its standard error for BNP were calculated to assess the relationship between BNP and radiotherapy for breast cancer patients. RESULTS: In total, 172 patients with breast cancer were identified. The pooled SMD was -0.233 (95% CI -1.113, -0.057). The pooled estimated SMD for all studies showed obvious significant difference (z = 3.99, P = .000). There was no publication bias. CONCLUSIONS: This meta-analysis suggested that BNP could be a biomarker of cardiac damage at high heart absorbed doses according to radiotherapy, especially for left breast cancer patients.
No takes yet. Share an insight, caveat, or question.
Zhang et al. (2019) conducted a meta-analysis in Left breast cancer (n=172). Radiotherapy vs. Baseline or no radiotherapy was evaluated on Brain natriuretic peptide (BNP) changes after radiotherapy (SMD -0.233, 95% CI -1.113 to -0.057, p=0.000). Radiotherapy significantly increased plasma levels of brain natriuretic peptide (BNP) in patients with left breast cancer (SMD -0.233), suggesting its potential as a biomarker for cardiac damage.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: