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May 8, 2010Journal of Cardiovascular Electrophysiology

Nonparoxysmal atrial fibrillation predicted a higher risk of AF recurrence after radiofrequency ablation compared to paroxysmal AF (RR 1.59; 95% CI 1.38-1.82; P<0.001).

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Why the study?

What are the preprocedure predictors of atrial fibrillation recurrence after radiofrequency catheter ablation?

Population

Patients undergoing radiofrequency ablation for atrial fibrillation across 31 studies and 25 studies.

Comparison

Radiofrequency catheter ablation vs Paroxysmal vs nonparoxysmal AF

Design

Meta-analysis

Key result

Nonparoxysmal atrial fibrillation predicted a higher risk of AF recurrence after radiofrequency ablation compared to paroxysmal AF (RR 1.59; 95% CI 1.38-1.82; P<0.001).

Authors

EBEthan M. BalkAGAnn C. GarlitskiAAAlawi Alsheikh‐Ali

Discussion

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Overview

Nonparoxysmal AF warrants closer post-ablation monitoring; confirms its independent predictive value across studies.

Study Design

Type

Systematic Review

Structured PICO

What are the preprocedure predictors of atrial fibrillation recurrence after radiofrequency catheter ablation?

P
Population
Patients undergoing radiofrequency ablation for atrial fibrillation across 31 studies (meta-analysis of univariable rates) and 25 studies (multivariable analyses).
I
Intervention
Radiofrequency catheter ablation
C
Comparator
Paroxysmal vs nonparoxysmal AF (evaluating predictors)
O
Outcome
Atrial fibrillation recurrencehard clinical

Main Result

Effect estimate: RR 1.59 (95% CI 1.38-1.82)

p-value: p=<0.001

Nonparoxysmal AF is a significant predictor of AF recurrence after radiofrequency ablation, whereas age, gender, and structural heart disease were not independent predictors in typical patient populations.

Limitations

  • Evaluation of predictors was limited by exclusion of patients with severe heart disease or at the age extremes
  • Highly heterogeneous studies regarding ablation technique and definition of AF recurrence
  • Exclusion of patients with severe heart disease or at the age extremes

Cite This Study

Balk et al. (2010) conducted a systematic review in Atrial fibrillation. Nonparoxysmal AF vs. Paroxysmal AF was evaluated on Atrial fibrillation recurrence (RR 1.59, 95% CI 1.38-1.82, p=<0.001). Nonparoxysmal atrial fibrillation predicted a higher risk of AF recurrence after radiofrequency ablation compared to paroxysmal AF (RR 1.59; 95% CI 1.38-1.82; P<0.001).

synapsesocial.com/papers/6a0f024d53f874f2b2231000https://doi.org/10.1111/j.1540-8167.2010.01798.x
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