Key result
ICD atrial auto-threshold algorithm paradoxically induces VF in a patient with LQTS3.
Why the study?
Implantable cardioverter-defibrillators are used to prevent sudden cardiac death in LQTS, but device-related factors can sometimes paradoxically trigger pro-arrhythmic effects.
Case Report (n=1)
Device-related factors, such as an atrial auto-threshold algorithm, can paradoxically have a pro-arrhythmic effect and induce ventricular fibrillation in patients with long QT syndrome.
Answers are grounded in this paper and cite their sources.
Raises caution for atrial auto-threshold algorithms in long QT syndrome type 3; leaves open device safety implications.
Patients with Long QT Syndrome (LQTS) are at increased risk for life-threatening arrhythmias. The ionic current abnormalities characteristic of LQTS lead to an enhancement in the transmural dispersion of the repolarization process in the myocardium, setting the stage for life-threatening ventricular arrhythmias.1 Although implantable cardioverter-defibrillators (ICDs) are occasionally used to prevent sudden cardiac death in these patients, device-related factors can sometimes paradoxically have a pro-arrhythmic effect.
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Cecchini et al. (2025) conducted a case report in Long QT syndrome type 3 (n=1). ICD with atrial auto-threshold algorithm was evaluated on Ventricular fibrillation. An atrial auto-threshold algorithm in an implantable cardioverter-defibrillator paradoxically induced ventricular fibrillation in a patient with long QT syndrome type 3.
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