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November 7, 2007Nucleic Acids Research151 citationsOpen Access

LOCATE: a mammalian protein subcellular localization database

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JSJanina SprengerJFJ. Lynn FinkSKS. M. Karunaratne

Key Points

  • To provide a curated database that details the subcellular localization of mouse and human proteins.
  • Curated data through the RIKEN FANTOM Consortium Isoform Protein Sequence sets
  • Included computational predictions and automated classification of localization data
  • Allowed third-party submission of literature data.
  • Database contains localization data for 20% of the mouse proteome and general annotation for 36%
  • Includes 58,128 mouse and 64,637 human protein isoforms
  • Provides localization data for individual subcellular compartments.

Abstract

LOCATE is a curated, web-accessible database that houses data describing the membrane organization and subcellular localization of mouse and human proteins. Over the past 2 years, the data in LOCATE have grown substantially. The database now contains high-quality localization data for 20% of the mouse proteome and general localization annotation for nearly 36% of the mouse proteome. The proteome annotated in LOCATE is from the RIKEN FANTOM Consortium Isoform Protein Sequence sets which contains 58 128 mouse and 64 637 human protein isoforms. Other additions include computational subcellular localization predictions, automated computational classification of experimental localization image data, prediction of protein sorting signals and third party submission of literature data. Collectively, this database provides localization proteome for individual subcellular compartments that will underpin future systematic investigations of these regions. It is available at http://locate.imb.uq.edu.au/

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Cite This Study

Sprenger et al. (2007) studied this question.

synapsesocial.com/papers/6a0f031d218372ada647e7a0https://doi.org/10.1093/nar/gkm950
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