What question did this study set out to answer?

To evaluate the association between free-living dietary composition, particularly saturated fatty acid intake and overall diet quality, and plasma lipoprotein(a) levels in healthy adults.

March 29, 2023Open Access

Association of Free-Living Diet Composition and Plasma Lipoprotein(a) Levels in Healthy Adults

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To evaluate the association between free-living dietary composition, particularly saturated fatty acid intake and overall diet quality, and plasma lipoprotein(a) levels in healthy adults.
Assessed dietary composition in 28 diverse adults (Black: n=18, Hispanic: n=7, White: n=3; mean age 48.3±12.5 years; 17 males) using 24-hour recalls analyzed via the Nutrition Data System for Research.
Calculated overall diet quality using Healthy Eating Index (HEI) scores and quantified fasting plasma lipoprotein(a) via isoform-independent ELISA.
Median plasma lipoprotein(a) concentration was 79.9 nmol/L (interquartile range: 34.4–146.0 nmol/L).
Lipoprotein(a) levels correlated inversely with absolute saturated fatty acid intake (R = -0.43, p = 0.02), percentage of calories from saturated fat (R = -0.38, p = 0.04), absolute palmitic acid (R = -0.38, p = 0.04), and absolute stearic acid (R = -0.40, p = 0.03).
Analyses of Healthy Eating Index component scores stratified by lipoprotein(a) thresholds (>100 vs. ≤100 nmol/L) revealed no statistically significant associations.

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Implication

Observational study finds an inverse link between dietary saturated fat intake and plasma lipoprotein(a) in diverse healthy adults, suggesting complex nutrient effects on cardiovascular risk.

Cite This Study

Matveyenko et al. (2023) studied this question.

synapsesocial.com/papers/6a0f0366a14f152feafa26a7 https://doi.org/10.1101/2023.03.24.23287725

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Implication

Observational study finds an inverse link between dietary saturated fat intake and plasma lipoprotein(a) in diverse healthy adults, suggesting complex nutrient effects on cardiovascular risk.

Association of Free-Living Diet Composition and Plasma Lipoprotein(a) Levels in Healthy Adults

Key Points

Discussion

Implication

Cite This Study

Association of Free-Living Diet Composition and Plasma Lipoprotein(a) Levels in Healthy Adults

Key Points

Discussion

Implication

Cite This Study

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