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December 30, 2024Journal of Cardiovascular ElectrophysiologyOpen Access

Quantification of atrial cardiomyopathy disease severity by electroanatomic voltage mapping and cardiac magnetic resonance imaging

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Key result

Both Atrial-EAVM and Atrial-LGE are linked to ~2% higher post-ablation arrhythmia recurrence.

  • HR 1.02
  • 95% CI 1.01-1.04
  • P=0.047
  • n=123

Why the study?

Atrial-LGE and Atrial-EAVM quantify anatomical and functional atrial cardiomyopathy, but the relationships between these modalities and their outcomes in patients with AF undergoing ablation required exploration.

Do Atrial-LGE and Atrial-EAVM correlate in quantifying atrial cardiomyopathy and predict arrhythmia recurrence in patients with atrial fibrillation undergoing first-time ablation?

Population

123 patients with AF undergoing first-time ablation

Comparison

Atrial-LGE vs Atrial-EAVM disease quantification

Design

Observational study

Authors

ISIain SimJSJosé Alonso Solís-LemusCOChristopher O’Shea

Discussion

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Member takes

Overview

May inform post-AF ablation recurrence risk via atrial fibrosis measures; leaves open incremental value and optimal clinical integration.

Study Design

Type

Observational (n=123)

Structured PICO

Do Atrial-LGE and Atrial-EAVM correlate in quantifying atrial cardiomyopathy and predict arrhythmia recurrence in patients with atrial fibrillation undergoing first-time ablation?

P
Population
123 patients with atrial fibrillation undergoing first-time ablation, mean age 60 ± 10 years.
I
Intervention
Quantification of atrial cardiomyopathy disease severity using Atrial-LGE (cardiac magnetic resonance imaging) and Atrial-EAVM (electroanatomic voltage mapping)
O
Outcome
Correlation between Atrial-LGE and Atrial-EAVM, and their association with arrhythmia recurrence following ablation

Main Result

Effect estimate: HR 1.02 (95% CI 1.01-1.04)

p-value: p=0.047

Atrial-EAVM and Atrial-LGE are moderately correlated in quantifying atrial cardiomyopathy, with agreement dependent on disease severity, and both modalities predict arrhythmia recurrence after first-time AF ablation.

Cite This Study

Sim et al. (2024) conducted an observational in atrial fibrillation (n=123). Atrial-LGE and Atrial-EAVM was evaluated on recurrence of arrhythmia following ablation (HR 1.02, 95% CI 1.01-1.04, p=0.047). Both Atrial-EAVM and Atrial-LGE were associated with arrhythmia recurrence following ablation (Atrial-LGE HR 1.02, 95% CI 1.01-1.04; Atrial-EAVM HR 1.02, 95% CI 1.005-1.03).

synapsesocial.com/papers/6a0f03b02eca052da64804c2https://doi.org/10.1111/jce.16462
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Automated analysis of atrial late gadolinium enhancement imaging that correlates with endocardial voltage and clinical outcomes: A 2-center study2013 · 152 citations
  2. 2Extent and spatial distribution of left atrial arrhythmogenic sites, late gadolinium enhancement at magnetic resonance imaging, and low-voltage areas in patients with persistent atrial fibrillation: comparison of imaging vs. electrical parameters of fibrosis and arrhythmogenesis2019 · 81 citations
  3. 3Adjunctive low‐voltage area ablation for patients with atrial fibrillation: An updated meta‐analysis of randomized controlled trials2024 · 15 citations
  4. 4Loss of Continuity in the Thin Epicardial Layer Because of Endomysial Fibrosis Increases the Complexity of Atrial Fibrillatory Conduction2013 · 137 citations
  5. 5Low‐voltage areas detected by high‐density electroanatomical mapping predict recurrence after ablation for paroxysmal atrial fibrillation2017 · 104 citations