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February 1, 1994Journal of Cardiovascular Electrophysiology

Initiating Reentry:

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Population

Rabbit AV node model and theoretical models of cardiac reentry

Design

Preclinical

Key result

Nonuniform anisotropic cellular coupling provides the functionally different pathways necessary for small cardiac reentrant circuits (<10-15 mm2), including those in the AV node.

Authors

MSMadison S. SpachMJMark E. Josephson

Discussion

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Overview

May refine AV nodal reentry models beyond repolarization; leaves open translation to human mechanisms or therapies.

Key Points

  • This research aims to establish the role of cellular coupling and nonuniform anisotropy in cardiac reentry.
  • Conducted microscopic extracellular measurements in the AV node of rabbits to assess anisotropic properties.
  • Reviewed experimental and theoretical models of cardiac reentry focusing on cellular coupling.
  • Analyzed conduction properties, including size and pathways of reentrant circuits.
  • Identified nonuniform anisotropic conduction properties in the AV node with significant variations.
  • Demonstrated that nonuniform anisotropic coupling can enable reentry in smaller areas (< 10-15 mm2).
  • Proposed reevaluation of the pathways in small reentrant circuits considering nonuniform anisotropic cellular coupling.

Structured PICO

P
Population
Rabbit AV node model and theoretical models of cardiac reentry
I
Intervention
Microscopic extracellular measurements of conduction properties
O
Outcome
Conduction properties (presence of nonuniform anisotropic conduction)surrogate

Nonuniform anisotropic cellular coupling, rather than just repolarization inhomogeneities, plays a critical role in the initiation of small reentrant circuits like those in the AV node.

Cite This Study

Spach et al. (1994) conducted a review in Cardiac arrhythmias and reentry. Nonuniform anisotropic cellular coupling provides the functionally different pathways necessary for small cardiac reentrant circuits (<10-15 mm2), including those in the AV node.

synapsesocial.com/papers/6a0f03b22eca052da64804cahttps://doi.org/10.1111/j.1540-8167.1994.tb01157.x
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Interaction of inhomogeneities of repolarization with anisotropic propagation in dog atria. A mechanism for both preventing and initiating reentry.1989 · 169 citations
  2. 2Influence of the passive anisotropic properties on directional differences in propagation following modification of the sodium conductance in human atrial muscle. A model of reentry based on anisotropic discontinuous propagation.1988 · 336 citations
  3. 3Cellular uncoupling can unmask dispersion of action potential duration in ventricular myocardium. A computer modeling study.1989 · 172 citations
  4. 4Anisotropic Reentry in a Perfused 2-Dimensional Layer of Rabbit Ventricular Myocardium2000 · 49 citations
  5. 5A microstructural model of reentry arising from focal breakthrough at sites of source-load mismatch in a central region of slow conduction2014 · 24 citations