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November 21, 2000CirculationOpen Access

Anisotropic Reentry in a Perfused 2-Dimensional Layer of Rabbit Ventricular Myocardium

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Population

Langendorff-perfused epicardial sheet created by freezing the intramural layers of the rabbit left ventricle

Comparison

Programmed electrical stimulation or rapid pacing vs Intact left ventricle (before freezing)

Design

Preclinical

Key result

In a 2D layer of anisotropic rabbit ventricular myocardium, programmed electrical stimulation induced sustained VT (cycle length 130±11 ms) caused by reentry around a functional line of block.

Authors

MSMartin J. SchalijLBLucas V.A. BoersmaMHM. Huijberts

Discussion

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Overview

Hypothesis-generating for functional reentry in anisotropic myocardium; clinical relevance in human VT remains undetermined.

Key Points

  • This study investigates how anisotropic conditions affect electrical propagation and facilitate reentry in myocardial tissue.
  • Created a Langendorff-perfused epicardial sheet of rabbit myocardium (n=35).
  • Constructed epicardial activation maps using high-resolution mapping arrays.
  • Recorded monophasic action potentials during electrical stimulation and rapid pacing.
  • Sustained ventricular tachycardia (VT) induced after freezing the myocardium with a cycle length of 130±11 ms.
  • Reentry occurred around a functional line of block, maintained refractory by electrotonic currents.
  • An excitable gap of 30 ms was created at pivot points of the line of block due to wave-front curvature.

Structured PICO

P
Population
Langendorff-perfused epicardial sheet created by freezing the intramural layers of the rabbit left ventricle (n=35)
I
Intervention
Programmed electrical stimulation or rapid pacing
C
Comparator
Intact left ventricle (before freezing)
O
Outcome
Induction and characteristics of reentrant tachycardia (VT)surrogate

In uniform anisotropic myocardium, reentry around a functional Z-shaped line of block can occur, with the core kept refractory by electrotonic currents.

Cite This Study

Schalij et al. (2000) studied Ventricular tachycardia / Reentry (n=35). Freezing intramural layers and programmed electrical stimulation vs. Intact left ventricle was evaluated on Induction of sustained VT and characteristics of reentry. In a 2D layer of anisotropic rabbit ventricular myocardium, programmed electrical stimulation induced sustained VT (cycle length 130±11 ms) caused by reentry around a functional line of block.

synapsesocial.com/papers/6a157a0337103a43379fcae9https://doi.org/10.1161/01.cir.102.21.2650
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Interaction of Transmembrane Potentials in Canine Purkinje Fibers and at Purkinje Fiber-Muscle Junctions1969 · 179 citations
  2. 2PROPAGATED REPOLARIZATION IN HEART MUSCLE1958 · 108 citations
  3. 3Initiating Reentry:1994 · 267 citations
  4. 4Effects of activation sequence and anisotropic cellular geometry on the repolarization phase of action potential of dog ventricular muscles.1987 · 101 citations
  5. 5Interaction of inhomogeneities of repolarization with anisotropic propagation in dog atria. A mechanism for both preventing and initiating reentry.1989 · 169 citations