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December 2, 2021Clinical Research in Cardiology14 citationsOpen Access

Determinants of fibrotic atrial cardiomyopathy in atrial fibrillation. A multicenter observational study of the RETAC (reseau européen de traîtement d’arrhythmies cardiaques)-group

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Why the study?

Can a simple clinical scoring system (AF-SCORE) predict fibrotic atrial myopathy and ablation success in patients with atrial fibrillation?

Population

958 patients with atrial fibrillation

Design

Cohort

Authors

BMBjörn Müller‐EdenbornZMZoraida Moreno‐WeidmannSVSandrine Venier

Discussion

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Overview

AF-SCORE may aid FAM risk stratification before PVI; hypothesis-generating and requires prospective validation before clinical use.

Study Design

Type

Observational (n=958)

Randomization

1:1 to derivation or mapping-validation cohort

Multicenter

Yes

Structured PICO

Can a simple clinical scoring system (AF-SCORE) predict fibrotic atrial myopathy and ablation success in patients with atrial fibrillation?

P
Population
958 patients with symptomatic paroxysmal or persistent atrial fibrillation undergoing first pulmonary vein isolation, followed for a mean of 421 days to derive and validate the AF-SCORE.
E
Exposure
AF-SCORE risk stratification model (points assigned for age ≥ 60 years, female sex, and AF-persistency)
O
Outcome
Presence of fibrotic atrial myopathy (FAM) and arrhythmia-freedom following pulmonary vein isolation (PVI)

The AF-SCORE, a simple clinical tool based on age, sex, and AF persistency, can effectively predict the presence of fibrotic atrial myopathy and the success of pulmonary vein isolation in patients with atrial fibrillation.

Main Result

Effect estimate: c-statistic 0.792

Cite This Study

Müller‐Edenborn et al. (2021) conducted an observational in Atrial fibrillation (n=958). AF-SCORE (Age, sex, and AF-phenotype) vs. Low AF-SCORE was evaluated on Prediction of fibrotic atrial myopathy (FAM) in the external mapping-validation cohort (c-statistic 0.792).

synapsesocial.com/papers/6a0f05ac218372ada647e918https://doi.org/10.1007/s00392-021-01973-1
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Also Consider

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