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May 9, 2023Frontiers in Cardiovascular MedicineOpen Access

Exercise training markedly increases cardiorespiratory fitness and lower-body strength in post-menopausal women versus controls.

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Why the study?

Cardiorespiratory fitness and muscular strength decline with age and menopause, posing CVD risks, but previous meta-analyses on exercise benefits in post-menopausal women remain inconclusive.

Does exercise training improve cardiorespiratory fitness and muscular strength in post-menopausal women?

Population

7,141 post-menopausal women across 129 RCTs

Comparison

Exercise training vs control

Design

Systematic review and meta-analysis of randomized controlled trials

Key result

Exercise training effectively increased cardiorespiratory fitness (SMD 1.15) and lower-body muscular strength (SMD 1.06) in post-menopausal women compared to non-exercise controls.

Authors

MKMousa KhalafiMSMohammad Hossein SakhaeiAMAref Habibi Maleki

Discussion

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Overview

Supports recommending exercise training for post-menopausal women; confirms large effects on fitness and strength from Level 1 evidence.

Study Design

Type

Meta-Analysis (n=7,141)

Structured PICO

Does exercise training improve cardiorespiratory fitness and muscular strength in post-menopausal women?

P
Population
7,141 post-menopausal women from 129 RCTs, with mean age ranging from ~53 to 90 years and BMI 22 to 35 kg/m2.
I
Intervention
Exercise training (aerobic, resistance, or combined training)
C
Comparator
Control group
O
Outcome
Cardiorespiratory fitness (CRF), lower- and upper-body muscular strength, and/or handgrip strengthsurrogate

Main Result

Effect estimate: SMD 1.15 (95% CI 0.87, 1.42)

p-value: p=0.001

Exercise training, including aerobic and resistance modalities, significantly improves cardiorespiratory fitness and muscular strength in post-menopausal women, offering potential cardioprotective benefits.

Limitations

  • Included studies regardless of the methods and units of measurement of outcomes, which did not allow the use of WMD for calculation of effect sizes
  • Significant heterogeneity indicated for all results, possibly due to differences in ages, health statuses, exercise protocols, and measurement methods

Cite This Study

Khalafi et al. (2023) conducted a meta-analysis in Post-menopausal women (n=7,141). Exercise training vs. Non-exercise control was evaluated on Cardiorespiratory fitness (CRF) (SMD 1.15, 95% CI 0.87, 1.42, p=0.001). Exercise training effectively increased cardiorespiratory fitness (SMD 1.15) and lower-body muscular strength (SMD 1.06) in post-menopausal women compared to non-exercise controls.

synapsesocial.com/papers/6a0f07c71c5e2d2319fa40cahttps://doi.org/10.3389/fcvm.2023.1190187
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