Effect of serum osmolality on 6-year survival rates in patients with acute myocardial

Aim: In the present study, we aimed to evaluate the potential relationship between serum osmolality and mortality rates in a six year of follow-up in patients with a history of acute myocardial infarction. Material and Methods: A retrospective study was designed. Participants were the patients with a first attack AMI, who were referred to our tertiary referral center for angiography. The relationship between the biochemical values of patients who were hospitalized between the period January 2008 - June 2009 and their survival in six years was investigated. Clinical variables of baseline characteristics, in-hospital management, and in-hospital adverse outcomes were recorded. Results: Two hundred and four patients, 174 men (85%) and 30 women (15%), were included in the study. Median serum osmolality was 295.87 mOsm/kg. Mean follow-up time was 61.31±1.68 months. The best cut-off value of the plasma osmolality to predict the 6-year mortality was 303.94 mOsmol/kg. Conclusion: The higher the osmolality, the worse the six-year survival is in patients with first episode AMI even in the absence of diabetes mellitus and chronic kidney disease. We believe that hyperosmolality can be targeted in treatment and prevention efforts as well as its use when evaluating outcomes of the cardiac diseases.