Key result
Dense echocardiographic contrast, appendage thrombus, and complex aortic plaque predicted ischemic stroke, while adjusted-dose warfarin reduced stroke risk by 75% in patients with plaque (P=0.02).
Why the study?
Does adjusted-dose warfarin compared to low-intensity warfarin plus aspirin reduce ischemic stroke in high-risk atrial fibrillation patients with specific TEE findings?
RCT (n=382)
Yes
Does adjusted-dose warfarin compared to low-intensity warfarin plus aspirin reduce ischemic stroke in high-risk atrial fibrillation patients with specific TEE findings?
TEE findings such as dense spontaneous echocardiographic contrast, appendage thrombus, and aortic plaque predict thromboembolism in high-risk AF patients, and adjusted-dose warfarin effectively reduces stroke risk in those with complex plaque.
No takes yet. Share an insight, caveat, or question.
May aid TEE-based stroke risk stratification in AF; leaves open optimal anticoagulation intensity for patients with complex plaque.
A 1998 study conducted an RCT in Nonvalvular Atrial Fibrillation (n=382). Adjusted-dose warfarin vs. low-intensity warfarin (international normalized ratio, 1.2 to 1.5) plus aspirin (325 mg/d) was evaluated on ischemic stroke. Dense echocardiographic contrast, appendage thrombus, and complex aortic plaque predicted ischemic stroke, while adjusted-dose warfarin reduced stroke risk by 75% in patients with plaque (P=0.02).
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