Hexagonal Multielectrode Design for Recording Local Electrograms With Superior Characteristics

Q: What is the clinical evidence from this study?

Population: Basic electrophysiology (n=1). Intervention: Triangular coaxial electrograms (hexagonal multielectrode) vs. Bipolar electrograms. Primary outcome: Activation time within 2 ms of unipolar gold standard.

Mark G. Hoogendijk; Ruben Coronel; Rishi Arora; Marion Kuiper; Natasja de Groot; Rudolf A. de Boer; Edward J. Vigmond; Bastiaan J. Boukens

doi:10.1016/j.jacep.2025.03.011

May 14, 2025JACC. Clinical electrophysiologyOpen Access

Hexagonal Multielectrode Design for Recording Local Electrograms With Superior Characteristics

View Full Paper

Ask AI

Bookmark

Share

Key result

Triangular coaxial electrograms match gold-standard local activation times in ~96% of cases, outperforming bipolar recordings.

n=1

Figures

Why the study?

Electrograms recorded with a local coaxial reference offer advantages over bipolar electrograms for activation mapping but require more electrodes.

Does a hexagonal multielectrode design recording triangular coaxial electrograms improve activation mapping characteristics compared to bipolar electrograms in a porcine heart model?

Key Points

To determine whether coaxial electrograms can be recorded efficiently using a triangular local reference derived from hexagonal multielectrode grids without the limitations of standard bipolar recordings.
Configured a triangular local reference using a hexagonal multielectrode grid layout to record local coaxial electrograms.
Compared signal recordings between triangular and cross-shaped local references using a custom multielectrode.
Evaluated electrogram morphology and activation timing accuracy relative to the activation front angle compared to conventional bipolar electrograms.
Local electrogram recordings using triangular and cross-shaped references were virtually indistinguishable from each other.
Coaxial electrogram morphology was insensitive to electrode orientation relative to the activation front, unlike standard bipolar electrograms.
Recorded activation times matched closely with local tissue activation.

Structured PICO

Does a hexagonal multielectrode design recording triangular coaxial electrograms improve activation mapping characteristics compared to bipolar electrograms in a porcine heart model?

P

Population

Explanted porcine heart (n=1) perfused in a Langendorff setup.

I

Intervention

Coaxial electrograms recorded with a triangular local reference using a custom hexagonal multielectrode grid.

C

Comparator

Bipolar electrograms and cross-shaped local reference coaxial electrograms.

O

Outcome

Morphology sensitivity to electrode orientation and accuracy of local activation time.surrogate

Main Result

Absolute Event Rate: 96% vs 86%

A novel hexagonal multielectrode design recording triangular coaxial electrograms provides orientation-independent morphology and precise local activation timing, potentially improving clinical activation mapping.

Limitations

Further in vivo validation will be required before their use is considered during invasive electrophysiological procedures.

Ask about this paper

Answers are grounded in this paper and cite their sources.

Implication

Triangular coaxial electrograms improve timing accuracy in porcine models; leaves open translation to clinical activation mapping.

Abstract

Electrograms recorded with a local coaxial reference offer advantages over bipolar electrograms for activation mapping but require more electrodes. We demonstrate that these coaxial electrograms can be recorded with a triangular local reference that can be efficiently created using hexagonal multielectrode grids. Triangular and cross-shaped local references recorded with a custom multielectrode were virtually indistinguishable. In contrast to bipolar electrograms, the morphology of the coaxial electrograms was insensitive to electrode orientation relative to the activation front, and the activation time matched closely with local activation. Developing hexagonal multielectrode designs may improve the efficiency and precision of clinical activation mapping.

Discussion

No takes yet. Share an insight, caveat, or question.

Cite This Study

Hoogendijk et al. (2025) studied Basic electrophysiology (n=1). Triangular coaxial electrograms (hexagonal multielectrode) vs. Bipolar electrograms was evaluated on Activation time within 2 ms of unipolar gold standard. Triangular coaxial electrograms recorded with a hexagonal multielectrode matched local activation time better than bipolar electrograms, with 96% versus 86% falling within 2 ms of the gold standard.

synapsesocial.com/papers/6a0f0d48c12540356222e377 https://doi.org/10.1016/j.jacep.2025.03.011

View Full Paper

Ask AI

Bookmark

Share

Hexagonal Multielectrode Design for Recording Local Electrograms With Superior Characteristics

Figures

Key Points

Structured PICO

Main Result

Limitations

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Hexagonal Multielectrode Design for Recording Local Electrograms With Superior Characteristics

Figures

Key Points

Structured PICO

Main Result

Limitations

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Keep reading

Keep reading