Key result
Vector Field Heterogeneity metric outperforms Spatial Inhomogeneity Index for capturing heterogeneous wavefronts in preclinical models.
Why the study?
Impaired cardiac tissue is often characterized by abnormal electrical conduction causing locally disorganized propagation wavefronts, creating a need for a parameter to quantify this using high-density multielectrode catheters.
Does the Vector Field Heterogeneity metric improve the assessment of locally disorganised cardiac electrical propagation wavefronts compared to the Spatial Inhomogeneity Index in simulations and rabbit hearts?
Does the Vector Field Heterogeneity metric improve the assessment of locally disorganised cardiac electrical propagation wavefronts compared to the Spatial Inhomogeneity Index in simulations and rabbit hearts?
The novel Vector Field Heterogeneity metric offers a superior method for quantifying disorganized cardiac electrical propagation, potentially enhancing the utility of high-density multielectrode catheters in electrophysiology.
May refine wavefront disorganization assessment in preclinical models; leaves open human validation.
High-density multielectrode catheters are becoming increasingly popular in cardiac electrophysiology for advanced characterisation of the cardiac tissue, due to their potential to identify impaired sites. These are often characterised by abnormal electrical conduction, which may cause locally disorganised propagation wavefronts. To quantify it, a novel heterogeneity parameter based on vector field analysis is proposed, utilising finite differences to measure direction changes between adjacent cliques. The proposed Vector Field Heterogeneity metric has been evaluated on a set of simulations with controlled levels of organisation in vector maps, and a variety of grid sizes. Furthermore, it has been tested on animal experimental models of isolated Langendorff-perfused rabbit hearts. The proposed parameter exhibited superior capturing ability of heterogeneous propagation wavefronts compared to the classical Spatial Inhomogeneity Index, and simulations proved that the metric effectively captures gradual increments in disorganisation in propagation patterns. In particular, it provided robust and consistent results for given with 4 × 4 grid sizes, which makes it suitable for new-generation orientation-independent cardiac catheters.
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Pancorbo et al. (2023) studied Abnormal electrical conduction. Vector Field Heterogeneity metric vs. Spatial Inhomogeneity Index was evaluated on Capturing ability of heterogeneous propagation wavefronts. The Vector Field Heterogeneity metric exhibited superior capturing ability of heterogeneous propagation wavefronts compared to the classical Spatial Inhomogeneity Index in simulations and rabbit hearts.
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