Why the study?
Does anticoagulant therapy improve extracellular matrix remodeling and cardiac function in patients with Q-wave myocardial infarction after thrombolysis?
Cohort (n=97)
No
Does anticoagulant therapy improve extracellular matrix remodeling and cardiac function in patients with Q-wave myocardial infarction after thrombolysis?
Anticoagulant therapy after thrombolysis for Q-wave myocardial infarction may reduce myocardial matrix degradation and improve left ventricular function.
Should not yet change post-MI anticoagulation choices; leaves open whether biomarker-level differences in matrix.
Aim. Matrix metalloproteinases play a key role in adaptive postinfarction remodeling of the heart. In order to study the influence of anticoagulation therapy on the state of matrix metalloproteinases and their inhibitors, the incidence of post-infarction aneurysm and thrombus formation in the left ventricle of patients with Q-wave myocardial infarction after thrombolytic therapy was studied.Methods and results. 97 patients took part in the study. Serum levels of matrix metalloproteinases and their inhibitors were evaluated by immunoassay analysis. Echocardiography was used for remodeling, systolic and diastolic function of the heart evaluation.Conclusion. Under the influence of the treatment reduction in the intensity of the degradation of connective tissue matrix of the myocardium was showed. That was accompanied by improvement in left ventricular systolic function and transformation of diastolic dysfunction into a pseudonormal type.
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S. M. Kyselov (2014) conducted a cohort in Acute Q-wave myocardial infarction (n=97). Unfractionated heparin vs. Fondaparinux (2.5 mg/day) or Enoxaparin (1 mg/kg every 12 hours) was evaluated on Serum TIMP-1 level at day 10 (pg/ml) (p=<0.05).
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