Key result
Serum MMP-1 and TIMP-1 levels dropped >1 SD below control values initially, peaked around day 14, and their rise correlated with left ventricular ejection fraction after acute myocardial infarction.
Why the study?
Do time-dependent changes in serum MMP-1 and TIMP-1 after successful reperfusion of acute myocardial infarction correlate with left ventricular remodelling?
Population
13 consecutive patients with their first acute myocardial infarction who underwent successful reperfusion.
Design
Cohort
Follow-up
4 weeks
Authors
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Post-MI MMP-1/TIMP-1 changes associate with LVEF; hypothesis-generating for remodeling biomarkers, prospective validation required before clinical use.
Observational (n=13)
Do time-dependent changes in serum MMP-1 and TIMP-1 after successful reperfusion of acute myocardial infarction correlate with left ventricular remodelling?
Serum MMP-1 and TIMP-1 levels show significant time-dependent changes after acute myocardial infarction and correlate with left ventricular remodelling parameters.
Hirohata et al. (1997) conducted an observational in Acute myocardial infarction (n=13). Serum MMP-1 and TIMP-1 levels dropped >1 SD below control values initially, peaked around day 14, and their rise correlated with left ventricular ejection fraction after acute myocardial infarction.
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