Key result
The upper quartile of day 3 TIMP-1 levels was associated with a significantly higher odds of having a large infarct size (adjusted OR 5.0; 95% CI 1.2-20.6).
Cohort (n=243)
Odds Ratio: 5 (95% CI 1.2–20.6)
Elevated TIMP-1 levels 3 days post-STEMI are associated with larger infarct size and higher NT-proBNP, suggesting a role in adverse cardiac remodeling.
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Day-3 TIMP-1 levels were associated with larger infarct size; leaves open incremental prognostic value beyond troponin in STEMI.
Opstad et al. (2017) conducted a cohort in Acute ST-Elevation Myocardial Infarction (n=243). Upper quartile of day 3 TIMP-1 levels vs. Lower quartiles of day 3 TIMP-1 levels was evaluated on Large infarct size (OR 5.0, 95% CI 1.2-20.6). The upper quartile of day 3 TIMP-1 levels was associated with a significantly higher odds of having a large infarct size (adjusted OR 5.0; 95% CI 1.2-20.6).
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