Key result
The activity of MMP-2 and MMP-9 is elevated during the acute phase of STEMI and significantly falls 12 hours after successful primary PCI, without acute changes immediately following abrupt vessel opening.
Why the study?
Does primary percutaneous coronary intervention affect the dynamics of MMP-2, MMP-9, TIMP-1, and TIMP-2 activity in patients with STEMI?
Observational (n=125)
No
Does primary percutaneous coronary intervention affect the dynamics of MMP-2, MMP-9, TIMP-1, and TIMP-2 activity in patients with STEMI?
p-value: p=<0.05
Elevated pre-procedural MMP-9 activity in STEMI patients is associated with a higher risk of the no-reflow phenomenon and lower LVEF at discharge following primary PCI.
No takes yet. Share an insight, caveat, or question.
Acute MMP-2/9 dynamics unchanged immediately post-PCI in STEMI; leaves open whether MMP modulation affects no-reflow or remodeling.
Kuliczkowski et al. (2013) conducted an observational in ST-elevation myocardial infarction (STEMI) (n=125). ST-elevation myocardial infarction treated with primary PCI vs. Healthy volunteers and stable CAD patients was evaluated on Dynamics of MMP-2 and MMP-9 activity at 12, 24, and 48 hours post-pPCI compared to baseline (p=<0.05). The activity of MMP-2 and MMP-9 is elevated during the acute phase of STEMI and significantly falls 12 hours after successful primary PCI, without acute changes immediately following abrupt vessel opening.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: