July 4, 2011Heart
Early measurements of plasma matrix metalloproteinase-2 predict infarct size and ventricular dysfunction in ST-elevation myocardial infarction
Key result
Early circulating levels of plasma MMP-2 measured before and after primary PCI were significantly correlated with infarct size and left ventricular dysfunction at 5 days and 4 months in STEMI patients.
Why the study?
Do early measurements of plasma MMP-2 predict infarct size and ventricular dysfunction in patients with STEMI undergoing primary PCI?
Population
58 patients with ST-elevation myocardial infarction undergoing primary percutaneous coronary intervention
Design
Cohort
Follow-up
4 months
Authors
Discussion
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Implication
Early MMP-2 levels may aid post-STEMI risk stratification; leaves open clinical utility pending prospective validation.
Study Design
Type
Cohort (n=58)
Structured PICO
Do early measurements of plasma MMP-2 predict infarct size and ventricular dysfunction in patients with STEMI undergoing primary PCI?
P
Population
58 patients with STEMI undergoing primary PCI, with cardiac MRI follow-up at 5 days and 4 months.
E
Exposure
Measurement of circulating matrix metalloproteinases (MMPs), tissue inhibitors of metalloproteinases (TIMPs), and myeloperoxidase (MPO) at baseline (before PCI), 12, 24, and 48 hours
O
Outcome
Infarct size, left ventricular dysfunction, and remodelling assessed by cardiac MRI at 5 days and 4 months after STEMIsurrogate
Early measurement of plasma MMP-2 before and shortly after primary PCI in STEMI patients predicts subsequent infarct size and left ventricular dysfunction.
Cite This Study
Nilsson et al. (2011) conducted a cohort in ST-elevation myocardial infarction (STEMI) (n=58). Plasma MMP-2 levels was evaluated on Infarct size and left ventricular dysfunction assessed by cardiac MRI. Early circulating levels of plasma MMP-2 measured before and after primary PCI were significantly correlated with infarct size and left ventricular dysfunction at 5 days and 4 months in STEMI patients.