Key result
Ischemia-reperfusion during CABG is linked to increased MMP-2/9 activity and impaired cardiac mechanical function.
Why the study?
Matrix metalloproteinases and their inhibitors regulate matrix remodelling and play a pivotal role in myocardial dysfunction following ischaemia-reperfusion injury, but changes in humans were not well characterized.
Does ischaemia-reperfusion injury during coronary artery bypass grafting activate matrix metalloproteinases and correlate with myocardial dysfunction in humans?
Comparison
Myocardial and plasma MMP and TIMP activity before bypass vs after reperfusion
Design
Observational cohort study
Follow-up
24 hours following reperfusion
Authors
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Increased MMP activity during CABG reperfusion was associated with early dysfunction; leaves open whether MMP inhibition mitigates stunning.
Observational (n=15)
Does ischaemia-reperfusion injury during coronary artery bypass grafting activate matrix metalloproteinases and correlate with myocardial dysfunction in humans?
Ischaemia-reperfusion injury during CABG activates matrix metalloproteinases in the human heart, which correlates with early postoperative myocardial stunning and dysfunction.
Lalu et al. (2004) conducted an observational in Stable angina undergoing coronary artery bypass graft surgery (n=15). Ischaemia-reperfusion injury during CABG vs. Baseline (prior to bypass) was evaluated on Changes in MMPs and TIMPs activities. Ischaemia-reperfusion injury during CABG significantly increased MMP-2 and MMP-9 activities and decreased TIMP-1, correlating inversely with cardiac mechanical function.
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