Key result
Dilated cardiomyopathy hearts exhibited an 80% reduction in TIMP-1 and intracardiomyocyte localization of MMP-2 and MMP-9, suggesting involvement in contractile apparatus disorganization.
Case-Control (n=12)
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No immediate clinical implications in DCM; leaves open whether MMP/TIMP modulation alters progression.
Rouet‐Benzineb et al. (1999) conducted a case-control in Dilated Cardiomyopathy (n=12). Dilated cardiomyopathy hearts exhibited an 80% reduction in TIMP-1 and intracardiomyocyte localization of MMP-2 and MMP-9, suggesting involvement in contractile apparatus disorganization.
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