Key result
Early MMP-2 decline predicts post-AMI LV reverse remodeling with ~92% sensitivity.
Why the study?
The relationship between serum levels of MMP and TIMP and left ventricular reverse remodeling after acute myocardial infarction has not been sufficiently examined.
Do early changes in serum matrix metalloproteinase-2 predict left ventricular reverse remodeling after an acute myocardial infarction?
Observational (n=40)
Do early changes in serum matrix metalloproteinase-2 predict left ventricular reverse remodeling after an acute myocardial infarction?
Effect estimate: AUC 0.82
p-value: p=<0.01
Early changes in serum MMP-2 levels from day 1 to day 7 can accurately predict left ventricular reverse remodeling at 6 months in patients with successfully reperfused acute myocardial infarction.
∆MMP-2 may predict post-MI LV reverse remodeling; hypothesis-generating and requires prospective validation before clinical use.
BACKGROUND: The relationship between the serum levels of matrix metalloproteinase (MMP) and tissue inhibitors of MMP (TIMP) and left ventricular (LV) reverse remodeling (LV-RR) after an acute myocardial infarction (AMI) has not been sufficiently examined. METHODS AND RESULTS: In 25 patients with successful reperfusion after an AMI and 15 normal control subjects, the serum MMP-2 and TIMP-2 levels were measured on days 1, 2, 3, and 7 and at 1 and 6 months after the AMI onset. LV-RR was defined as a >15% decrease in the LV end-systolic volume index at 6 months after the AMI. The MMP-2 level on day 1 and TIMP-2 levels throughout the study period were comparable between the patients with and without LV-RR. The MMP-2 on day 7 (P<0.05) and the changes in the MMP-2 from day 1 to day 7 (∆MMP-2; P<0.01) were lower in patients with than in those without LV-RR. The ∆MMP-2 was strongly correlated with the changes in the LV volume and ejection fraction from 1 month to 6 months after the AMI. The ∆MMP-2 value of <-158.5 ng/mL predicted LV-RR with a high accuracy (91.7% sensitivity and 76.9% specificity; area under the curve=0.82). CONCLUSIONS: Changes in MMP-2 are associated with LV-RR after an AMI. The ΔMMP-2 might be a useful predictor of subsequent LV-RR.
No takes yet. Share an insight, caveat, or question.
Morishita et al. (2015) conducted an observational in Acute Myocardial Infarction (n=40). Changes in MMP-2 from day 1 to day 7 (∆MMP-2) vs. Patients without left ventricular reverse remodeling was evaluated on Left ventricular reverse remodeling (LV-RR) defined as a >15% decrease in the LV end-systolic volume index at 6 months (AUC 0.82, p=<0.01). A change in MMP-2 from day 1 to day 7 of <-158.5 ng/mL predicted left ventricular reverse remodeling at 6 months post-AMI with 91.7% sensitivity and 76.9% specificity (AUC=0.82).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: