Increased Serum Matrix Metalloproteinase-1 Concentration Predicts Advanced Left Ventricular Remodeling in Patients With Acute Myocardial Infarction.
Why the study?
Does serum MMP-1 concentration predict left ventricular remodeling (LVEF) after acute myocardial infarction?
Population
24 patients with their first acute myocardial infarction (AMI)
Design
Cohort
Follow-up
4 weeks
Authors
Discussion
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Member takes
Implication
Serum MMP-1 may flag higher post-AMI remodeling risk; hypothesis-generating and requires prospective validation before clinical use.
Structured PICO
Does serum MMP-1 concentration predict left ventricular remodeling (LVEF) after acute myocardial infarction?
P
Population
24 patients with their first acute myocardial infarction (AMI)
I
Intervention
Measurement of serum matrix metalloproteinase-1 (MMP-1) concentration at multiple time points (admission, 24 h, 3 days, 7 days, 2 weeks, and 4 weeks)
O
Outcome
Left ventricular ejection fraction (LVEF) at 4 weeks after the onset of AMI, calculated by center line method on left ventriculographysurrogate
High serum MMP-1 concentrations in the subacute phase after a first AMI are associated with lower LVEF at 4 weeks, suggesting its utility as a biomarker for advanced left ventricular remodeling.
Cite This Study
Soejima et al. (2003) studied this question.