Key result
Post-MI MMP-9 levels fail to correlate with early left ventricular remodeling.
Why the study?
The prognostic value of serum matrix metalloproteinase-9 in left ventricular remodeling during the hospital period of acute myocardial infarction was unclear.
Observational (n=36)
Yes
Effect estimate: R=0.12
p-value: p=0.47
Null result in Level 5 study leaves MMP-9's prognostic role in post-MI remodeling open; larger prospective trials needed before clinical use.
Serum matrix metalloproteinase-9 (MMP-9) was assayed at 3-4 days after the first acute myocardial infarction symptoms onset in 36 patients (40-72 years old, 83% male, 89% ST-elevation). Serum concentration of MMP-9 had association with neither sizes nor function of the left ventricular of the heart (LV) assessed by echocardiography performed during hospital admission and before discharge. In contrast, anterior infarction, higher arterial blood pressure during index admission and wall motion index score (WMIS) turned to have positive correlation with LV sizes.
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Труфанов et al. (2012) conducted an observational in Acute myocardial infarction (n=36). Serum matrix metalloproteinase-9 (MMP-9) concentration was evaluated on Correlation between MMP-9 level and relative change in left ventricular end-diastolic dimension (ΔEDD) (R=0.12, p=0.47). Serum concentration of matrix metalloproteinase-9 on days 3-4 of acute myocardial infarction did not correlate with early post-infarction left ventricular remodeling during the hospital period.
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