Key result
Early improvement in left ventricular ejection fraction during immunosuppressive treatment for myocarditis predicted an 83% survival rate at three years, regardless of histological resolution.
Why the study?
Does histological resolution of myocarditis correlate with improvement in ventricular function in patients with myocarditis receiving immunosuppressive treatment?
Population
20 patients with documented myocarditis, heart failure of less than six months' duration, and left…
Comparison
Immunosuppressive treatment vs Ongoing myocarditis vs resolved myocarditis on…
Design
Cohort
Follow-up
Mean 79 days for repeat biopsy, at least 3 years for…
Authors
Loading...
Early LVEF response may inform prognosis during immunosuppression for myocarditis; leaves open whether histological resolution should guide therapy.
Cohort (n=20)
Does histological resolution of myocarditis correlate with improvement in ventricular function in patients with myocarditis receiving immunosuppressive treatment?
Histological resolution of myocarditis is not required for LVEF improvement during immunosuppressive treatment, and early LVEF improvement predicts excellent long-term survival.
Dec et al. (1988) conducted a cohort in myocarditis (n=20). Immunosuppressive treatment was evaluated on Changes in left ventricular ejection fraction and histological findings on repeat endomyocardial biopsy. Early improvement in left ventricular ejection fraction during immunosuppressive treatment for myocarditis predicted an 83% survival rate at three years, regardless of histological resolution.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: