What question did this study set out to answer?

To systematically analyze and contrast gene expression profiles of immune- and inflammation-related pathways across multiple brain regions in normal aging and Alzheimer disease.

July 23, 2012Journal of NeuroinflammationOpen Access

Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study

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Authors

DCDavid H. CribbsUniversity of California, Irvine NBNicole C. BerchtoldAlpine Immune Sciences (United States)VPVictoria M. PerreauSIB Swiss Institute of Bioinformatics

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Implication

Microarray profiling reveals extensive innate immune activation during normal brain aging surpassing changes in Alzheimer disease, indicating chronic inflammation precedes clinical dementia.

Key Points

To systematically analyze and contrast gene expression profiles of immune- and inflammation-related pathways across multiple brain regions in normal aging and Alzheimer disease.
Conducted microarray gene expression profiling across postmortem brain tissues from young donors (aged 20 to 59 years), older adults (aged 60 to 99 years), and individuals with Alzheimer disease (aged 74 to 95 years).
Evaluated 759 immune-related probesets across four distinct brain regions: superior frontal gyrus, post-central gyrus, hippocampus, and entorhinal cortex.
Approximately 40% of the 759 immune probesets showed significant alteration across the superior frontal gyrus, post-central gyrus, and hippocampus during aging (64% to 86% upregulated), compared to only ~6% altered during the transition to Alzheimer disease.
Normal aging triggered widespread activation of microglia and perivascular macrophages across complement, toll-like receptor, inflammasome, and HLA pathways, alongside downregulation of inhibitory checkpoints TOLLIP and fractalkine.
Entorhinal cortex exhibited fewer statistically significant immune gene changes compared to other brain areas, and immune alterations demonstrated sex-specific response patterns.

Cite This Study

Cribbs et al. (2012) studied this question.

synapsesocial.com/papers/6a0f18921cf410a932425b81 https://doi.org/10.1186/1742-2094-9-179

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Implication

Microarray profiling reveals extensive innate immune activation during normal brain aging surpassing changes in Alzheimer disease, indicating chronic inflammation precedes clinical dementia.

Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study

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Implication

Key Points

Cite This Study

Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study

Discussion

Member takes

Implication

Key Points

Cite This Study

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