Key result
Rem inhibits CaV1.2 channels via three mechanisms: reducing surface density, decreasing open probability, and immobilizing voltage sensors, requiring distinct GTPase conformations.
Rem inhibits Ca(V)1.2 channels through three distinct mechanisms, providing mechanistic insights that could inform the development of novel calcium channel blockers.
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Does not inform clinical calcium channel blocker use; leaves open Rem conformations as targets for selective modulators.
Yang et al. (2010) studied CaV1.2 channel regulation. Rem (RGK GTPase) was evaluated on Mechanisms of CaV1.2 channel inhibition. Rem inhibits CaV1.2 channels via three mechanisms: reducing surface density, decreasing open probability, and immobilizing voltage sensors, requiring distinct GTPase conformations.
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