November 1, 2006Journal of Occupational and Environmental Medicine
Personal Coronary Risk Profiles Modify Autonomic Nervous System Responses to Air Pollution
Key result
Each 1-mg/m3 increase in PM2.5 exposure was associated with a 5.3 beats/min HR increase and 11.7% SDNN reduction (CI 6.2-17.1%), with 2- to 4-fold greater responses in high-risk subjects.
Why the study?
Does personal coronary risk profile modify the autonomic nervous system responses (HR and HRV) to PM2.5 exposure in male boilermakers?
Population
10 male boilermakers, mean age 34.3 +/- 8.1 years
Comparison
Personal PM2.5 exposure vs Low versus high coronary risk profiles
Design
Cohort
Follow-up
24-hour
Authors
Discussion
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Implication
Higher coronary risk may amplify PM2.5 autonomic effects; hypothesis-generating for targeted protections, pending prospective trials.
Study Design
Type
Observational (n=10)
Structured PICO
Does personal coronary risk profile modify the autonomic nervous system responses (HR and HRV) to PM2.5 exposure in male boilermakers?
P
Population
10 male boilermakers, mean age 34.3 +/- 8.1 years
I
Intervention
Personal PM2.5 exposure
C
Comparator
Low (Framingham score 1-3) versus high (Framingham score 5-6) coronary risk profiles
O
Outcome
Heart rate (HR) and heart rate variability (HRV, including SDNN, rMSSD, HF) measured from 24-hour ambulatory electrocardiogramssurrogate
Main Result
Effect estimate: 11.7% reduction for SDNN (95% CI 6.2-17.1%)
Adverse autonomic responses to PM2.5 exposure, such as increased heart rate and reduced heart rate variability, are significantly aggravated in individuals with higher coronary risk profiles.
Cite This Study
Chen et al. (2006) conducted an observational in Male boilermakers exposed to PM2.5 (n=10). PM2.5 exposure vs. Low vs high Framingham risk score was evaluated on Heart rate (HR) and heart rate variability (HRV) (11.7% reduction for SDNN, 95% CI 6.2-17.1%). Each 1-mg/m3 increase in PM2.5 exposure was associated with a 5.3 beats/min HR increase and 11.7% SDNN reduction (CI 6.2-17.1%), with 2- to 4-fold greater responses in high-risk subjects.