What is the clinical evidence from this study?

Study design: Cohort. Population: outflow tract premature ventricular contractions (n=90). Intervention: Metabolic syndrome vs. Without metabolic syndrome. Primary outcome: composite of recurrence of acute or delayed outflow tract ventricular arrhythmia (HR 9.655, 95% CI 3.000-31.068, p=<0.001).

December 1, 2014BMC Cardiovascular DisordersOpen Access

Metabolic syndrome linked to ~10-fold higher risk of outflow tract PVC recurrence after catheter ablation.

Q: What are the key findings of this study?

Metabolic syndrome was independently associated with a significantly higher risk of acute or delayed recurrence of outflow tract premature ventricular contractions after catheter ablation (HR 9.655).

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Why the study?

Does metabolic syndrome increase the recurrence of outflow tract PVCs after catheter ablation in patients without structural heart disease?

Population

90 patients with frequent premature ventricular contraction beats originating from right ventricular outflow…

Comparison

Presence of metabolic syndrome (n=24) vs Absence of metabolic syndrome (n=66)

Design

Cohort

Follow-up

mean 35 (17-43) months

Key result

Metabolic syndrome was independently associated with a significantly higher risk of acute or delayed recurrence of outflow tract premature ventricular contractions after catheter ablation (HR 9.655).

Authors

CSCelestino Sardu GCGiovanni Carreras SKSpyridon Katsanos

Discussion

Member takes

Overview

May support closer post-ablation surveillance in metabolic syndrome; leaves open whether metabolic intervention reduces outflow tract PVC recurrence.

Study Design

Type

Cohort (n=90)

Multicenter

Yes

Structured PICO

Does metabolic syndrome increase the recurrence of outflow tract PVCs after catheter ablation in patients without structural heart disease?

Population

90 patients with frequent premature ventricular contraction beats (PVCs) originating from right ventricular outflow tract (RVOT, n=68), left ventricular outflow tract (LVOT, n=19) or coronary cusps (CUSPs, n=3), with normal ventricular systolic function and absence of cardiac structural disease.

Intervention

Presence of metabolic syndrome (n=24)

Comparator

Absence of metabolic syndrome (n=66)

Outcome

Composite of recurrence of acute or delayed outflow tract ventricular arrhythmia: acute spontaneous or inducible outflow tract ventricular arrhythmia recurrence or recurrence of outflow tract PVCs in holter monitoring at follow upcomposite

Main Result

Effect estimate: HR 9.655 (95% CI 3.000-31.068)

p-value: p=<0.001

Metabolic syndrome is strongly associated with a higher recurrence rate of outflow tract PVCs after catheter ablation in patients without structural heart disease.

Limitations

Episodes of asymptomatic PVCs or more serious arrhythmias might have been missed during follow-up
Study sample size and follow-up duration may have been insufficient to fully characterize the incidence of lethal arrhythmias
Patients were not followed for any status change in their metabolic syndrome component
Waist circumference measurement data was not obtained
Number of subjects and ages in the study and control groups were not similar

Cite This Study

Sardu et al. (2014) conducted a cohort in outflow tract premature ventricular contractions (n=90). Metabolic syndrome vs. Without metabolic syndrome was evaluated on composite of recurrence of acute or delayed outflow tract ventricular arrhythmia (HR 9.655, 95% CI 3.000-31.068, p=<0.001). Metabolic syndrome was independently associated with a significantly higher risk of acute or delayed recurrence of outflow tract premature ventricular contractions after catheter ablation (HR 9.655).

synapsesocial.com/papers/6a0f20f5a7a2fed64abdbc72 https://doi.org/10.1186/1471-2261-14-176

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December 1, 2014BMC Cardiovascular DisordersOpen Access

Metabolic syndrome linked to ~10-fold higher risk of outflow tract PVC recurrence after catheter ablation.

View Full Paper

Ask AI

Bookmark

Why the study?

Does metabolic syndrome increase the recurrence of outflow tract PVCs after catheter ablation in patients without structural heart disease?

Population

90 patients with frequent premature ventricular contraction beats originating from right ventricular outflow…

Comparison

Presence of metabolic syndrome (n=24) vs Absence of metabolic syndrome (n=66)

Design

Cohort

Follow-up

mean 35 (17-43) months

Key result

Metabolic syndrome was independently associated with a significantly higher risk of acute or delayed recurrence of outflow tract premature ventricular contractions after catheter ablation (HR 9.655).

Authors

CSCelestino Sardu GCGiovanni Carreras SKSpyridon Katsanos

Discussion

Member takes

Overview

May support closer post-ablation surveillance in metabolic syndrome; leaves open whether metabolic intervention reduces outflow tract PVC recurrence.

Study Design

Type

Cohort (n=90)

Multicenter

Yes

Structured PICO

Does metabolic syndrome increase the recurrence of outflow tract PVCs after catheter ablation in patients without structural heart disease?

Population

Intervention

Presence of metabolic syndrome (n=24)

Comparator

Absence of metabolic syndrome (n=66)

Outcome

Main Result

Effect estimate: HR 9.655 (95% CI 3.000-31.068)

p-value: p=<0.001

Metabolic syndrome is strongly associated with a higher recurrence rate of outflow tract PVCs after catheter ablation in patients without structural heart disease.

Limitations

Episodes of asymptomatic PVCs or more serious arrhythmias might have been missed during follow-up
Study sample size and follow-up duration may have been insufficient to fully characterize the incidence of lethal arrhythmias
Patients were not followed for any status change in their metabolic syndrome component
Waist circumference measurement data was not obtained
Number of subjects and ages in the study and control groups were not similar

Cite This Study

synapsesocial.com/papers/6a0f20f5a7a2fed64abdbc72 https://doi.org/10.1186/1471-2261-14-176

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

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