Exercise electrocardiography demonstrated limited diagnostic usefulness for coronary artery disease, yielding false-negative results in 67% of patients with clinically suspected disease.
Cross-Sectional (n=89)
Does exercise electrocardiography accurately predict coronary artery disease compared to coronary angiography in patients with Type II hyperlipoproteinemia?
Exercise electrocardiography has limited diagnostic usefulness due to frequent false-negative responses in patients with clinically suspected coronary disease and frequent false-positive responses in asymptomatic patients.
The electrocardiographic response to exercise was compared with the results of coronary angiography in 89 patients with Type II hyperlipoproteinemia who had previous myocardial infarction or typical angina or both (43 patients)(Group A), "atypical angina" (16 patients)(Group B)or positive electrocardiographic response to exercise without other evidence of cardiac disease (30 patients)(Group C). Thirty-nine of 43 in Group A had greater than or equal to 50 per cent stenosis, and 26 (67%) of these 39 had negative exercise tests. In Group B, five of the 16 had greater than or equal to 50% stenosis, and three had positive exercise tests (one patient had a false-positive test). In Group C, eleven of 30(37%) had greater than or equal to 50% stenosis; however, nine (30%) had minor stenosis (less than or equal to 50%), and 10(33%) normal coronary arteries. The diagnostic usefulness of exercise electrocardiography is limited. False-negative responses are frequent in patients with clinically suspected coronary disease, and false-positive responses frequent in asymptomatic patients.
Borer et al. (1975) conducted a cross-sectional in Type II hyperlipoproteinemia with suspected or asymptomatic coronary artery disease (n=89). Exercise electrocardiography vs. Coronary angiography was evaluated on Presence of greater than or equal to 50 per cent coronary stenosis on angiography compared to exercise electrocardiography response. Exercise electrocardiography demonstrated limited diagnostic usefulness for coronary artery disease, yielding false-negative results in 67% of patients with clinically suspected disease.
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