What question did this study set out to answer?

To examine lesion correlates of acute speech deficits following left versus right hemisphere ischemic stroke and clarify bilateral neural contributions to early language dysfunction.

December 13, 2025Brain SciencesOpen Access

Lesion-Symptom Mapping of Acute Speech Deficits After Left vs. Right Hemisphere Stroke: A Retrospective Analysis of NIHSS Best Language Scores and Clinical Neuroimaging

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To examine lesion correlates of acute speech deficits following left versus right hemisphere ischemic stroke and clarify bilateral neural contributions to early language dysfunction.
Retrospective analysis of 410 ischemic stroke patients (225 left, 185 right hemisphere lesions) from the Stroke Outcome Optimization Project dataset.
Speech deficits were evaluated within 48 hours of onset using the National Institutes of Health Stroke Scale (NIHSS) Best Language subscore alongside clinical MRI scans normalized to MNI space.
Voxelwise and region-of-interest lesion-symptom mapping were conducted using permutation correction (5,000 iterations; p < 0.05) controlling for total lesion volume.
Speech deficits occurred in 53.7% of the total cohort, affecting 58.2% of left hemisphere and 48.1% of right hemisphere stroke patients.
Deficit severity localized predominantly to left hemisphere structures, with peak associations in the external capsule (Z = 6.39), posterior insula (Z = 5.64), and inferior fronto-occipital fasciculus (Z = 5.43).
Right hemisphere deficits mapped to homologous regions, including the posterior insula (Z = 3.70) and external capsule (Z = 3.63), presenting milder symptoms despite larger lesion volumes than left hemisphere strokes.

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Implication

Retrospective analysis reveals acute speech deficits from right-hemisphere damage in stroke patients, challenging traditional left-dominant models of language impairment.

Cite This Study

Sherzad et al. (2025) studied this question.

synapsesocial.com/papers/6a0f243c4994b59e774262ae https://doi.org/10.3390/brainsci15121329

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Implication

Retrospective analysis reveals acute speech deficits from right-hemisphere damage in stroke patients, challenging traditional left-dominant models of language impairment.

Lesion-Symptom Mapping of Acute Speech Deficits After Left vs. Right Hemisphere Stroke: A Retrospective Analysis of NIHSS Best Language Scores and Clinical Neuroimaging

Key Points

Discussion

Implication

Cite This Study

Lesion-Symptom Mapping of Acute Speech Deficits After Left vs. Right Hemisphere Stroke: A Retrospective Analysis of NIHSS Best Language Scores and Clinical Neuroimaging

Key Points

Discussion

Implication

Cite This Study

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