Human Radiation-Induced Eye Diseases: A Scoping Review towards “In-silico” Experimental Studies

This article delves into how certain human tissues, as the eye's lens, are prone to damage from radiation. Notably, the eye's lens has shown a significant vulnerability to low- LET radiation through a variety of processes. There's been an effort by the International Commission on Radiological Protection (ICRP) to revise the guidelines on acceptable limits for high-LET radiation exposure. The article offers important perspectives on how radiation affects human tissues, emphasizing the necessity for correct radiation exposure guidelines. It also examines the potential impact of radiation on other eye diseases and the development of cataracts among health workers, flight personnel, and astronauts. According to this review results, more international work thought epidemiological studies is needed additionally to alternative approaches combining advanced computational modeling techniques and medical imaging data, we may be able to develop accurate computer models capable of simulating how radiation interacts with the eye. This could offer valuable insights into the root causes of radiation-induced eye diseases and aid in refining radiation protection strategies.