Key result
CENTERA valve shows ~99% 30-day survival and low new pacemaker need in severe AS.
Why the study?
Increasing numbers of patients undergoing TAVI warranted continued technological improvements in transcatheter heart valve systems.
Does the CENTERA self-expanding THV improve outcomes in patients with severe symptomatic aortic stenosis?
Does the CENTERA self-expanding THV improve outcomes in patients with severe symptomatic aortic stenosis?
The CENTERA self-expanding THV is a competitive option for severe aortic stenosis, offering high 30-day survival and low rates of pacemaker implantation and paravalvular leak.
Answers are grounded in this paper and cite their sources.
May support CENTERA THV consideration in severe aortic stenosis; leaves open randomized comparisons with other valves.
Transcatheter aortic valve implantation (TAVI) is now an established treatment option for both high and intermediate operative risk patients with severe symptomatic aortic stenosis. The number of patients undergoing TAVI has increased over the last decade warranting continued technological improvements in transcatheter heart valve (THV) systems. The novel CENTERA self-expanding THV (Edwards Lifesciences, CA, USA) received CE approval this year. It is deliverable through a 14Fr sheath and has a unique motorized delivery system. The CENTERA-2 study results demonstrated a favorable survival rate at 30 days (99%), as well as a low need for new permanent pacemaker implantation (4.9%). 1-year outcomes reported a low incidence of >moderate paravalvular leak (0.6%) and consistently favorable THV hemodynamics making this a competitive THV for patients with severe aortic stenosis.
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Brennan et al. (2019) conducted a review in severe symptomatic aortic stenosis. CENTERA self-expanding THV was evaluated on survival rate at 30 days. The CENTERA self-expanding transcatheter heart valve demonstrated a 99% survival rate at 30 days and a 4.9% need for new permanent pacemaker implantation in patients with severe aortic stenosis.
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