What question did this study set out to answer?

Determine whether bacterial colonization contributes to fibrous capsular contracture around breast implants and evaluate the efficacy of intraluminal antibiotic diffusion in preventing contracture.

July 1, 1981Plastic & Reconstructive Surgery

Capsules, Infection, and Intraluminal Antibiotics

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Authors

BBBoyd R. BurkhardtAdobe Systems (United States)MFMary FriedThe Ohio State University PSPaul SchnurWinnMed

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Implication

Clinical study demonstrates reduced capsular contracture with intraluminal antibiotics in breast augmentation patients, suggesting low-grade infection drives capsule formation.

Key Points

Determine whether bacterial colonization contributes to fibrous capsular contracture around breast implants and evaluate the efficacy of intraluminal antibiotic diffusion in preventing contracture.
Cultured Staphylococcus epidermidis from surgical mammary pockets prior to implant placement and from interior fibrous capsules during open capsulotomy.
Evaluated in vitro outward diffusion of cephalothin and gentamicin across inflatable silicone implant shells.
Administered intraluminal cephalothin and gentamicin in vivo during primary mammary augmentation and secondary open capsulotomy procedures.
Staphylococcus epidermidis was isolated from 55% of pre-insertion surgical pockets and 71% of interior fibrous capsules at open capsulotomy.
Cephalothin and gentamicin diffused across the silicone elastomer shell in vitro.
In vivo intraluminal antibiotic administration significantly reduced the incidence of capsular contracture following primary augmentation and secondary capsulotomy.

Cite This Study

Burkhardt et al. (1981) studied this question.

synapsesocial.com/papers/6a0f2ce704e2b0ba896ca2e5 https://doi.org/10.1097/00006534-198107000-00010

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Implication

Clinical study demonstrates reduced capsular contracture with intraluminal antibiotics in breast augmentation patients, suggesting low-grade infection drives capsule formation.

Capsules, Infection, and Intraluminal Antibiotics

Discussion

Member takes

Implication

Key Points

Cite This Study

Capsules, Infection, and Intraluminal Antibiotics

Discussion

Member takes

Implication

Key Points

Cite This Study

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