What question did this study set out to answer?

The aim is to compare the efficacy and safety of tenecteplase versus alteplase for acute ischemic stroke in patients with large vessel occlusions.

December 4, 2020StrokeOpen Access

Intravenous Thrombolysis With Tenecteplase in Patients With Large Vessel Occlusions

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The aim is to compare the efficacy and safety of tenecteplase versus alteplase for acute ischemic stroke in patients with large vessel occlusions.
Conducted a systematic review and meta-analysis of randomized controlled trials.
Searched MEDLINE and Scopus for studies evaluating intravenous thrombolysis with tenecteplase or alteplase.
Included trials with confirmed large vessel occlusions and outcomes at 3 months.
Patients receiving tenecteplase had higher odds of modified Rankin Scale scores of 0 to 2 (OR 2.06, 95% CI 1.15–3.69).
Higher odds of successful recanalization with tenecteplase (OR 3.05, 95% CI 1.73–5.40).
No significant differences in early neurological improvement or rates of intracranial hemorrhage between the two groups.

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Systematic review compares tenecteplase and alteplase for acute ischemic stroke, indicating tenecteplase may improve outcomes.

Katsanos et al. (2020) studied this question.

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