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September 1, 2004Anesthesia & Analgesia

The Incidence of Awareness During Anesthesia: A Multicenter United States Study

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Key result

General anesthesia was associated with a 0.13% incidence of awareness with recall, with higher ASA physical status increasing this risk (OR 2.41; 95% CI 1.04-5.60).

Population

19,575 patients scheduled for surgery under general anesthesia at 7 academic medical centers in the United…

Design

Cohort

Follow-up

At least a week after anesthesia and surgery

Authors

PSPeter S. SebelUniversity of IowaABAndrew BowdleUniversity of WashingtonMGMohammed M. GhoneimAlfaisal University

Discussion

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Overview

Alerts clinicians to awareness risk in higher-ASA patients; extends incidence estimates in a large contemporary cohort.

Study Design

Type

Cohort (n=19,575)

Multicenter

Yes

Structured PICO

P
Population
19,575 patients scheduled for surgery under general anesthesia at 7 academic medical centers in the United States
I
Intervention
General anesthesia
O
Outcome
Incidence of awareness with recall during general anesthesiapatient reported

Main Result

Effect estimate: OR 2.41 (95% CI 1.04-5.60)

Awareness with recall during general anesthesia occurs in approximately 0.13% of surgical patients in the US, with higher risk observed in patients with greater ASA physical status.

Cite This Study

Sebel et al. (2004) conducted a cohort in Surgery under general anesthesia (n=19,575). General anesthesia was evaluated on Incidence of awareness with recall (OR 2.41, 95% CI 1.04-5.60). General anesthesia was associated with a 0.13% incidence of awareness with recall, with higher ASA physical status increasing this risk (OR 2.41; 95% CI 1.04-5.60).

synapsesocial.com/papers/6a0f2f3604e2b0ba896ca630https://doi.org/10.1213/01.ane.0000130261.90896.6c
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Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Awareness during Anesthesia2000 · 189 citations
  2. 2False Negative BIS? Maybe, Maybe Not!2001 · 9 citations
  3. 3Reduction in the incidence of awareness using BIS monitoring2003 · 399 citations
  4. 4Awareness and recall during general anesthesia2014 · 301 citations