Key result
MMP-2 and Pro-BNP levels decrease significantly over 30 days in patients with DM and AMI.
Why the study?
The study was planned to assess the levels of MMP-2 and Pro-BNP at different time intervals in patients with diabetes mellitus and acute myocardial infarction.
Do MMP-2 and Pro-BNP levels change over time in patients with diabetes mellitus and acute myocardial infarction compared to healthy volunteers?
Observational (n=86)
Do MMP-2 and Pro-BNP levels change over time in patients with diabetes mellitus and acute myocardial infarction compared to healthy volunteers?
MMP-2 and Pro-BNP levels show significant time-dependent decreases after acute myocardial infarction in diabetic patients, though Pro-BNP remains elevated at 90 days, highlighting their potential utility in monitoring post-AMI recovery.
Answers are grounded in this paper and cite their sources.
Observed MMP-2 and Pro-BNP declines may track post-AMI recovery in diabetes; leaves open prognostic utility in prospective studies.
Introduction: The present study has been planned to assess the levels of MMP-2 and Pro-BNP in patients suffering with Diabetes mellitus. the study showed that levels of above said inammatory biomarkers at different time intervals and it was rst to report the levels of biomarkers in AMI patients with DM. Material And Methods: 86 patients were selected and divided into two groups, Group A included 43 healthy volunteers, Group B included patients with DM and suffering from AMI. Blood concentration of biochemical parameters related to AMI was assessed at the baseline and levels of MMP-2 and Pro-BNP were assessed via ELISA kits at 0th , 30th ,60th and 90th day of the enrolment of DM patients with AMI. Results: Assessment of biochemical parameters were done and found signicantly increased levels was found in group B as compared to group A. Among the DM patients with AMI (conrmed as per guidelines) in group B, MMP-2 and Pro-BNP levels were found signicantly decreased on 0th day to 30th day (P=5.28E-16 and P=1.5E-22), 30th day to 60th day (P=1.04E-07and P=1.2E-30)and 60th day to 90th day (P=5.37E-05 and P=1.66E-12) respectively. Plasma levels of Pro-BNP and MMP-2 were correlated and Pro-BNP levels were still found signicantly increased on the 90th day of enrolment of DM patients. Discussion Time dependent relationships were found in Pro-BNP and MMP-2 serum levels, therefore these biomarkers were directly correlated with AMI. At 90th day, Pro-BNP levels were found signicantly increased as compared to healthy volunteers of group A.
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Singh et al. (2022) conducted an observational in Diabetes mellitus with acute myocardial infarction (n=86). MMP-2 and Pro-BNP assessment vs. Healthy volunteers was evaluated on Changes in MMP-2 and Pro-BNP levels at 0, 30, 60, and 90 days (p=5.28E-16). Plasma levels of MMP-2 and Pro-BNP in patients with diabetes mellitus and acute myocardial infarction significantly decreased from day 0 to day 30 (P=5.28E-16 and P=1.5E-22, respectively).
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