Key result
CMR-derived septum swing index is linked to ~12-fold higher odds of pulmonary hypertension.
Why the study?
Ventricular septal swinging motion is commonly seen on CMR cine sequences in PH, but the utility of a CMR-derived septum swing index for detecting PH needed assessment.
Does cardiac magnetic resonance imaging-derived septum swing index accurately detect pulmonary hypertension in patients with suspected PH?
Observational (n=105)
No
Does cardiac magnetic resonance imaging-derived septum swing index accurately detect pulmonary hypertension in patients with suspected PH?
Answers are grounded in this paper and cite their sources.
CMR-derived septum swing index is a highly accurate, non-invasive marker for detecting pulmonary hypertension, correlating well with invasive right heart catheterization.
Background and Objectives Because of pressure differences between the pulmonary artery and aorta, the ventricular septum moves in a swinging motion that is commonly observed on cardiac MR (CMR) cine sequences in patients with pulmonary hypertension (PH). We aimed to assess the use of septum swing index (SSI) derived by CMR for detecting PH. Methods We retrospectively identified consecutive patients with suspected PH who underwent right heart catheterization (RHC) and CMR at a PH referral center between July 2019 and December 2020. The diagnostic accuracy of SSI for identifying PH (mean pulmonary artery pressure [mPAP] ≥ 25 mmHg) was assessed by receiver operating characteristic curves, sensitivity, specificity, and positive and negative predictive values. Results A total of 105 patients (mean age: 47.8 ± 15.0 years; 68 females) were included in the final analysis. SSI and mPAP were negatively correlated in the total study population and patients with PH, but not in patients without PH. SSI was an independent predictor of PH (adjusted odds ratio: 12.9, 95% confidence interval: 3.6 to 45.5, P = 0.003). The area under the curve for SSI was 0.91, with a cut-off value of 0.9673 yielding the best balance of sensitivity (86.4%), specificity (88.2%), positive predictive value (97.4%), negative predictive value (55.6%), and accuracy (86.7%) for detecting PH. Conclusions Septum swing index was lower in patients with PH and is a simple, reliable method for detecting PH.
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He et al. (2023) conducted an observational in Suspected pulmonary hypertension (n=105). Septum swing index (SSI) derived by CMR was evaluated on Identifying pulmonary hypertension (mean pulmonary artery pressure ≥ 25 mmHg) (adjusted OR 12.9, 95% CI 3.6 to 45.5, p=0.003). Septum swing index derived by cardiac magnetic resonance imaging was an independent predictor of pulmonary hypertension (adjusted OR 12.9; 95% CI 3.6-45.5; P=0.003) with an AUC of 0.91.
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