Key result
Six months of antihypertensive treatment with losartan-based regimens significantly increased mean retinal arteriole diameter from 0.0842 mm to 0.0847 mm (p=0.001).
Why the study?
Does 6 months of treatment with losartan with or without hydrochlorothiazide improve retinal microcirculation calibres in hypertensive outpatients?
Observational (n=51)
Single-blind
No
Does 6 months of treatment with losartan with or without hydrochlorothiazide improve retinal microcirculation calibres in hypertensive outpatients?
Absolute Event Rate: 0.0847% vs 0.0842%
p-value: p=0.001
Six months of antihypertensive treatment with a losartan-based regimen significantly increased retinal arteriole diameter and arteriovenous ratio, suggesting regression of early hypertension-related microvascular alterations.
Should not yet change practice; hypothesis-generating for losartan effects on retinal microcirculation.
Evaluation of early hypertension-related alterations in retinal microcirculation has been subjective and poorly reproducible. The authors recently described a semiautomatic computerized system for evaluation of the calibre of retinal blood vessels that has shown very good reproducibility. In the study, this system was used to measure the calibres of retinal arterioles and veins, and their ratio, in a group of 51 hypertensive outpatients before and after 6 months of treatment with losartan or, if required for satisfactory blood pressure control, losartan plus hydrochlorothiazide. Mean retinal arteriole diameter increased from 0.0842 +/- 0.003 mm to 0.0847 +/- 0.003 mm (p = 0.001). Arteriovenous ratio increased from 0.753 +/- 0.03 to 0.756 +/- 0.03 (p = 0.005). This observation suggests regression of early hypertension-related alterations in retinal microcirculation after 6 months of antihypertensive treatment.
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Pose‐Reino et al. (2006) conducted an observational in Arterial Hypertension (n=51). Losartan +/- hydrochlorothiazide vs. Baseline was evaluated on Mean retinal arteriole diameter (mm) (p=0.001). Six months of antihypertensive treatment with losartan-based regimens significantly increased mean retinal arteriole diameter from 0.0842 mm to 0.0847 mm (p=0.001).
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