Key result
Transient and cyclic left ventricular pressure overload in a swine model induced a profibrotic signature and diffuse myocardial fibrosis that was not readily reversible after cessation of the stimulus.
Answers are grounded in this paper and cite their sources.
This editorial highlights that transient left ventricular pressure overload can induce persistent diffuse myocardial fibrosis, suggesting that removing the overload stimulus alone may be insufficient to reverse HFpEF-related structural changes.
No abstract yet. The journal hasn't published one we can show.
No takes yet. Share an insight, caveat, or question.
Francis G. Spinale (2025) conducted an editorial in Heart failure with preserved ejection fraction (HFpEF) and diffuse myocardial fibrosis. Transient and cyclic left ventricular pressure overload in a swine model induced a profibrotic signature and diffuse myocardial fibrosis that was not readily reversible after cessation of the stimulus.
Synapse has enriched 10 related papers. Consider them for comparative context: