Key result
Standard treatment containing carvedilol (mean 16 mg/day for 12 months) significantly improved both cardiac sympathetic nerve activity and left ventricular remodelling in patients with DCM.
Why the study?
Does standard treatment containing carvedilol improve cardiac sympathetic nerve activity and left ventricular remodelling in patients with dilated cardiomyopathy?
Population
30 patients with dilated cardiomyopathy (DCM) and 10 normal controls
Comparison
Standard treatment containing carvedilol at a… vs Pre-treatment baseline and 10 normal controls
Design
Cohort
Follow-up
mean 12 +/- 1 months
Authors
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Supports carvedilol regimens in DCM; hypothesis-generating without randomized confirmation of causality.
Observational (n=40)
Does standard treatment containing carvedilol improve cardiac sympathetic nerve activity and left ventricular remodelling in patients with dilated cardiomyopathy?
Long-term therapy including carvedilol improves both cardiac sympathetic nerve activity and left ventricular remodelling in patients with dilated cardiomyopathy.
Kasama et al. (2007) conducted an observational in Dilated cardiomyopathy (n=40). Standard treatment containing carvedilol vs. Baseline (pre-treatment) and normal controls was evaluated on Cardiac sympathetic nerve activity (123I-MIBG scintigraphic findings) and left ventricular remodelling (echocardiographic parameters). Standard treatment containing carvedilol (mean 16 mg/day for 12 months) significantly improved both cardiac sympathetic nerve activity and left ventricular remodelling in patients with DCM.
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