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September 1, 1996HeartOpen Access

Increased myocardial 123I-metaiodobenzylguanidine uptake after enalapril treatment in patients with chronic heart failure.

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Why the study?

Does enalapril improve cardiac sympathetic neuronal uptake function in patients with chronic, mild to moderate congestive heart failure?

Population

23 patients with chronic, mild to moderate, stable congestive heart failure and a left ventricular ejection…

Comparison

Enalapril for 6 weeks. vs Baseline measurements before enalapril treatment.

Design

Cohort

Follow-up

6 weeks

Authors

GSG. Aernout SomsenAmsterdam University Medical CentersBVBob van VliesMedisch Centrum LeeuwardenPMPaul A. de MillianoMaastricht University Medical Centre

Discussion

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Implication

Enalapril may enhance cardiac sympathetic function in mild-moderate HF; hypothesis-generating and requires RCT confirmation before practice change.

Structured PICO

Does enalapril improve cardiac sympathetic neuronal uptake function in patients with chronic, mild to moderate congestive heart failure?

P
Population
23 patients with chronic, mild to moderate, stable congestive heart failure (ischaemic or idiopathic) and a left ventricular ejection fraction <40%.
I
Intervention
Enalapril for 6 weeks.
C
Comparator
Baseline measurements before enalapril treatment (patients served as their own controls).
O
Outcome
Cardiac uptake of MIBG measured by single photon emission tomography (SPET).surrogate

Enalapril improves cardiac sympathetic neuronal uptake function in patients with mild to moderate heart failure, providing a potential mechanism for its beneficial effects.

Cite This Study

Somsen et al. (1996) studied this question.

synapsesocial.com/papers/6a774ff96789de8d0af7249bhttps://doi.org/10.1136/hrt.76.3.218

Topics

Heart failureHFrEF treatment
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The Neurohumoral Axis in Congestive Heart Failure1984 · 603 citations
  2. 2Cardiac sympathetic nervous activity in congestive heart failure. Evidence for increased neuronal norepinephrine release and preserved neuronal uptake.1993 · 227 citations
  3. 3Hormones regulating cardiovascular function in patients with severe congestive heart failure and their relation to mortality. CONSENSUS Trial Study Group.1990 · 1,158 citations
  4. 4Effects of Long-term Enalapril Therapy on Cardiac Structure and Function in Patients With Left Ventricular Dysfunction1995 · 475 citations
  5. 5In vivo measurement of neuronal uptake of norepinephrine in the human heart.1988 · 166 citations