What question did this study set out to answer?

To determine the distribution of the Hodgkin's disease-associated antigen Ki-1 in normal, reactive, and neoplastic human lymphoid tissues and clarify the cellular origin of Reed-Sternberg cells.

October 1, 1985BloodOpen Access

The expression of the Hodgkin's disease associated antigen Ki-1 in reactive and neoplastic lymphoid tissue: evidence that Reed-Sternberg cells and histiocytic malignancies are derived from activated lymphoid cells

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Authors

HSH SteinThe Honourable Society of Lincoln's Inn DMDY MasonUniversity of Perugia JGJohannes GerdesResearch Center Borstel - Leibniz Lung Center

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Implication

Laboratory analysis reveals Ki-1 antigen expression across lymphoid malignancies and activated lymphocytes, indicating Reed-Sternberg cells derive from activated lymphoid lineages.

Key Points

To determine the distribution of the Hodgkin's disease-associated antigen Ki-1 in normal, reactive, and neoplastic human lymphoid tissues and clarify the cellular origin of Reed-Sternberg cells.
Analyzed Ki-1 antigen expression using immunocytochemical techniques across normal tissues, mitogen- and virus-transformed lymphocytes, and 290 cases of malignant lymphoma.
Assessed T-cell, B-cell, macrophage, and epithelial markers alongside immunoglobulin gene configuration using JH-specific DNA hybridization probes.
Stimulated normal T and B lymphocytes in vitro using phytohemagglutinin, Staphylococcus aureus, Epstein-Barr virus, or human T leukemia viruses to assess antigen inducibility.
Ki-1 antigen was detected in all cases of lymphomatoid papulosis and angio-immunoblastic lymphadenopathy, in 28% of peripheral T-cell lymphomas, and strongly in 45 cases of diffuse large-cell lymphoma.
Among the 45 Ki-1-positive large-cell lymphoma cases, 35 expressed T-cell markers (nine coexpressing B-cell markers), seven expressed B-cell markers alone, and none expressed macrophage or epithelial antigens.
Ki-1 antigen and interleukin-2 receptor expression were co-induced on normal resting T and B lymphocytes following exposure to mitogens or transforming viruses.

Cite This Study

Stein et al. (1985) studied this question.

synapsesocial.com/papers/6a0f3ce911edbd3546bddd34 https://doi.org/10.1182/blood.v66.4.848.848

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Implication

Laboratory analysis reveals Ki-1 antigen expression across lymphoid malignancies and activated lymphocytes, indicating Reed-Sternberg cells derive from activated lymphoid lineages.

The expression of the Hodgkin's disease associated antigen Ki-1 in reactive and neoplastic lymphoid tissue: evidence that Reed-Sternberg cells and histiocytic malignancies are derived from activated lymphoid cells

Discussion

Member takes

Implication

Key Points

Cite This Study

The expression of the Hodgkin's disease associated antigen Ki-1 in reactive and neoplastic lymphoid tissue: evidence that Reed-Sternberg cells and histiocytic malignancies are derived from activated lymphoid cells

Discussion

Member takes

Implication

Key Points

Cite This Study

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