Key result
Linear temporal dilation of canine epicardial recordings generates electrograms physiologically similar to humans.
A novel time dilation technique allows canine epicardial recordings mapped to human torsos to mimic human electrophysiological timing, enabling investigation of human-like arrhythmias.
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Advances cross-species arrhythmia modeling; leaves open clinical translation pending validation.
Gillette et al. (2016) studied Cardiac arrhythmias (computational modeling) (n=10). Temporal dilation (linear and nonlinear) using global and local scaling factors vs. Original canine recordings was evaluated on Conduction velocity (CV), activation recovery interval (ARI), and total activation time (TAT). Linear temporal dilation of canine epicardial potential recordings using global scaling generated electrograms physiologically similar to humans in terms of conduction velocity and activation recovery interval.
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