Key result
Left ventricular hypertrophy was associated with a significantly higher risk of developing new-onset atrial fibrillation compared to normal subjects (RR 1.46).
Why the study?
The association between left ventricular hypertrophy and atrial fibrillation, specifically the predictive and prognostic role of LVH, required systematic evaluation.
Does left ventricular hypertrophy increase the risk of atrial fibrillation and worsen prognosis in patients with AF?
Meta-Analysis (n=133,091)
Does left ventricular hypertrophy increase the risk of atrial fibrillation and worsen prognosis in patients with AF?
Effect estimate: RR 1.46 (95% CI 1.32-1.60)
Left ventricular hypertrophy is strongly associated with an increased risk of developing atrial fibrillation and predicts worse outcomes, including higher mortality and recurrence after ablation.
Aims: The aim of this study was to perform a meta-analysis of studies of the association of left ventricular hypertrophy (LVH) and atrial fibrillation (AF), especially the predictive and prognostic role of LVH. Methods and Results: We searched Medline, Embase, and the Cochrane Library from inception through 10 April 2020. A total of 16 cohorts (133,091 individuals) were included. Compared with the normal subjects, patients with LVH were more susceptible to AF (RR = 1.46, 95% CI, 1.32–1.60). In patients with AF and LVH, there was a higher risk of all-cause mortality during 3.95 years (RR = 1.60, 95% CI, 1.42–1.79), and these patients were more likely to progress to persistent or paroxysmal AF (RR = 1.45, 95% CI, 1.20–1.76) than were patients without LVH. After catheter ablation of AF, patients with LVH were more likely to recur (RR = 1.58, 95% CI, 1.27–1.95). Conclusion: LVH is strongly associated with AF and has a negative impact on outcome in patients with AF.
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Xiang et al. (2021) conducted a meta-analysis in Atrial Fibrillation (n=133,091). Left ventricular hypertrophy (LVH) vs. No left ventricular hypertrophy was evaluated on Occurrence of Atrial Fibrillation (RR 1.46, 95% CI 1.32-1.60). Left ventricular hypertrophy was associated with a significantly higher risk of developing new-onset atrial fibrillation compared to normal subjects (RR 1.46).
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