Key result
In guinea pig hearts, repolarization spreads anisotropically along the epicardium with maximum (0.53 m/s) and minimum (0.31 m/s) velocities aligning with longitudinal and transverse fiber axes.
Population
Guinea pig hearts (intact hearts and perfused sheets)
Design
Preclinical
Authors
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Guinea pig data warrant caution before clinical translation; leaves open fiber orientation's role in human repolarization.
In guinea pig hearts, repolarization is guided by intrinsic spatial heterogeneities of action potential durations and spreads anisotropically according to epicardial fiber orientation.
Kanai et al. (1995) studied Electrophysiology of guinea pig hearts. Optical mapping and pacing was evaluated on Activation and repolarization velocities and patterns. In guinea pig hearts, repolarization spreads anisotropically along the epicardium with maximum (0.53 m/s) and minimum (0.31 m/s) velocities aligning with longitudinal and transverse fiber axes.
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