May 1, 2001Cardiovascular Research
Pharmacogenetics and drug-induced arrhythmias
Key result
Pharmacogenetics and genetic variants in drug disposition, targets, or biological systems modulate the variability in response to drugs used for treating sudden cardiac death.
Design
Review
Authors
Discussion
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Member takes
Implication
May inform genotype-guided dosing to mitigate drug-related SCD risk; leaves open prospective validation before practice change.
PICO
P
Population
Drug-induced arrhythmias and sudden cardiac death
Understanding the genetic basis of variability in drug response provides a framework for managing drug-induced arrhythmias and treating sudden cardiac death.
Cite This Study
Dan M. Roden (2001) conducted a review in Drug-induced arrhythmias and sudden cardiac death. Pharmacogenetics and genetic variants in drug disposition, targets, or biological systems modulate the variability in response to drugs used for treating sudden cardiac death.