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September 1, 1988Scandinavian Journal of Clinical and Laboratory Investigation

Lanthanides as probes for time-resolved fluorometric immunoassays

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Authors

IHIlkka HemmiläStatistics Finland

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Overview

Narrative review reveals improved diagnostic sensitivity using lanthanide probes in immunoassays, suggesting a powerful alternative to radioisotopes.

Key Points

  • To evaluate the use and advantages of lanthanide fluorescent probes as non-isotopic labels in time-resolved fluorometric immunoassays.
  • Reviewed advancements in immunoassay design focusing on monoclonal antibodies and two-site sandwich formats.
  • Analyzed the transition from traditional radioisotopic tracers to non-isotopic fluorescent labels including lanthanides.
  • Assay sensitivity and specificity improved markedly with the integration of monoclonal antibodies and two-site sandwich assay formats.
  • Lanthanide-based time-resolved fluorometric probes demonstrated growing utility as an effective, non-isotopic alternative to radioactive tracers.

Cite This Study

Ilkka Hemmilä (1988) studied this question.

synapsesocial.com/papers/6a0f4ae634fbf15957ed166ahttps://doi.org/10.1080/00365518809085747
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