A biomimetic strategy to modulate inter- and intramolecular Coulomb interactions of peptides allows for the reversible regulation of functions of peptide–polymer conjugates. Calcium ions are exploited as triggers to screen peptide charges, thereby switching the peptide secondary structure. This approach results in a reversible control mechanism for bioconjugate self-assembly. Disassembly is feasible by regulating the Ca2+ levels using competitive Ca2+ binders.
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Kühnle et al. (2011) studied this question.
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