Key result
Basic electrophysiologic studies demonstrate that pulmonary veins initiate atrial fibrillation through mechanisms including enhanced automaticity, triggered activity, and microreentry.
This review highlights the pathophysiological mechanisms, including enhanced automaticity and microreentry, by which pulmonary veins initiate atrial fibrillation.
Underpins pulmonary vein isolation in AF ablation; leaves open dominant mechanism in clinical practice.
The basic electrophysiologic studies have proved the arrhythmogenic mechanisms of the pulmonary vein as an atrial fibrillation initiator; the mechanisms include enhanced automaticity, triggered activity, and microreentry from myocardial sleeves inside pulmonary veins. Immunohistology study has proved the conduction characteristics of pulmonary vein myocardium, and further study of ionic currents are important for understanding atrial fibrillation initiation from the pulmonary vein.
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Chen et al. (2003) conducted a review in Atrial fibrillation. Basic electrophysiologic studies demonstrate that pulmonary veins initiate atrial fibrillation through mechanisms including enhanced automaticity, triggered activity, and microreentry.
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